Flucytosine: correlation between toxicity and pharmacokinetic parameters.
Chemotherapy
; 46(2): 86-94, 2000.
Article
em En
| MEDLINE
| ID: mdl-10671757
ABSTRACT
Flucytosine (5-fluorocytosine, 5-FC) is a systemic antimycotic drug the major toxicities of which are bone marrow depression and hepatotoxicity. The purpose of this observational and retrospective study was to assess a possible relationship between toxicity and 5-FC pharmacokinetics within a group of 53 intensive care unit patients. The presented results reveal that thrombocytopenia is associated with a decreased 5-FC clearance and that the thrombocyte nadir is linearly related to the 5-FC clearance. Furthermore, patients experiencing 5-FC levels exceeding 100 mg 5-FC/l were found to be at a higher risk of developing thrombocytopenia and hepatotoxicity as compared to those not exceeding this level.
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Base de dados:
MEDLINE
Assunto principal:
Flucitosina
Tipo de estudo:
Observational_studies
/
Risk_factors_studies
Limite:
Humans
Idioma:
En
Revista:
Chemotherapy
Ano de publicação:
2000
Tipo de documento:
Article
País de afiliação:
Holanda