hSKCa3: no association of the polymorphic CAG repeat with bipolar affective disorder and schizophrenia.
Psychiatr Genet
; 9(4): 169-75, 1999 Dec.
Article
em En
| MEDLINE
| ID: mdl-10697822
ABSTRACT
hSKCa3 is a neuronal small conductance calcium-activated potassium channel, which contains a polyglutamine tract, encoded by a polymorphic CAG repeat in the gene. Since an association between longer alleles of this CAG repeat and bipolar disorder or schizophrenia has been reported, we genotyped the polymorphic CAG repeat in 91 German family trios of patients with bipolar disorder I and used the transmission disequilibrium test (TDT) to test for association. Applying a dichotomized model (< or = 19 or > 19 CAG triplets), we found no evidence for an association of longer alleles with bipolar disorder (TDT = 0.75, P = 0.386). Regarding the whole range of alleles, there was no preference in transmitting the larger of the two observed alleles from parents to the affected offspring. In parallel we performed an independent case-control study on German patients with bipolar disorder and schizophrenia. Again we did not detect an overrepresentation of longer CAG repeats in patients. Thus, our data do not support the hypothesis that longer CAG repeats in the hSkCa3 gene contribute to the susceptibility for bipolar disorder and schizophrenia.
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Base de dados:
MEDLINE
Assunto principal:
Polimorfismo Genético
/
Esquizofrenia
/
Transtorno Bipolar
/
Neuropeptídeos
/
Canais de Potássio
/
Repetições de Trinucleotídeos
Tipo de estudo:
Clinical_trials
/
Observational_studies
/
Risk_factors_studies
Limite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
País/Região como assunto:
Europa
Idioma:
En
Revista:
Psychiatr Genet
Assunto da revista:
GENETICA
/
PSIQUIATRIA
Ano de publicação:
1999
Tipo de documento:
Article
País de afiliação:
Alemanha