Increased limbic blood flow and total sleep deprivation in major depression with melancholia.
Psychiatry Res
; 55(2): 101-9, 1994 Jun.
Article
em En
| MEDLINE
| ID: mdl-10711798
ABSTRACT
Single photon emission computed tomography (SPECT) with technetium-99m-d,l-hexamethyl-propylene amine oxime (99Tcm-HMPAO) was carried out in 20 melancholic patients before and after total sleep deprivation. Findings in 11 responders to total sleep deprivation (defined by > or = 40% improvement on the Hamilton Rating Scale for Depression) were compared with findings in nine nonresponders. On the basis of a semiquantitative evaluation of SPECT findings, responders showed relative hyperperfusion before sleep deprivation in the right anterior cingulate cortex and in the right and left fronto-orbital cortex and basal cingulate gyrus. Responders who showed > or = 50% improvement also showed hippocampal overactivation before sleep deprivation. It is possible that limbic overactivation may characterize depressed responders to total sleep deprivation as a distinct subtype. Another possibility is that the pattern of limbic hyperactivation reflects the increased number of bipolar patients in the responder group, with response to total sleep deprivation being only a covariate of this bipolar-unipolar distinction.
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Base de dados:
MEDLINE
Assunto principal:
Privação do Sono
/
Tomografia Computadorizada de Emissão de Fóton Único
/
Transtorno Depressivo Maior
/
Transtorno Depressivo
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Sistema Límbico
Limite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Psychiatry Res
Ano de publicação:
1994
Tipo de documento:
Article
País de afiliação:
Alemanha