Proximally targeted GABAergic synapses and gap junctions synchronize cortical interneurons.
Nat Neurosci
; 3(4): 366-71, 2000 Apr.
Article
em En
| MEDLINE
| ID: mdl-10725926
ABSTRACT
Networks of GABAergic interneurons are implicated in synchronizing cortical activity at gamma frequencies (30-70 Hz). Here we demonstrate that the combined electrical and GABAergic synaptic coupling of basket cells instantaneously entrained gamma-frequency postsynaptic firing in layers 2/3 of rat somatosensory cortex. This entrainment was mediated by rapid curtailment of gap junctional coupling potentials by GABAA receptor-mediated IPSPs. Electron microscopy revealed spatial proximity of gap junctions and GABAergic synapses on somata and dendrites. Electrical coupling alone entrained postsynaptic firing with a phase lag, whereas unitary GABAergic connections were ineffective in gamma-frequency phasing. These observations demonstrate precise spatiotemporal mechanisms underlying action potential timing in oscillating interneuronal networks.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Sinapses
/
Comunicação Celular
/
Junções Comunicantes
/
Ácido gama-Aminobutírico
/
Interneurônios
Limite:
Animals
Idioma:
En
Revista:
Nat Neurosci
Assunto da revista:
NEUROLOGIA
Ano de publicação:
2000
Tipo de documento:
Article
País de afiliação:
Hungria