The activation of B-Raf and Raf-1 after electroconvulsive shock in the rat hippocampus.

Kang, U G; Jeon, S H; Lee, J E; Joo, Y H; Yi, J S; Park, J B; Juhnn, Y S; Kim, Y S

Kang, U G; Jeon, S H; Lee, J E; Joo, Y H; Yi, J S; Park, J B; Juhnn, Y S; Kim, Y S.

Afiliação

Kang UG; Department of Psychiatry, Seoul National University College of Medicine, South Korea.

Neuropharmacology ; 39(4): 703-6, 2000 Feb 14.

Article em En | MEDLINE | ID: mdl-10728891

ABSTRACT

ABSTRACT

We demonstrated that ECS activates the kinase activity of B-Raf and Raf-1 in the rat hippocampus. The activity was maximal at one minute after ECS and temporally coincided with the increased membrane translocation of Rafs and the reported activity of MAPK, but not with the phosphorylation of Rafs.

Assuntos

Hipocampo/enzimologia; Proteínas Proto-Oncogênicas c-raf/metabolismo; Animais; Transporte Biológico; Membrana Celular/metabolismo; Eletrochoque; Hipocampo/metabolismo; Immunoblotting; Masculino; Fosforilação; Ratos; Ratos Sprague-Dawley

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Base de dados: MEDLINE Assunto principal: Proteínas Proto-Oncogênicas c-raf / Hipocampo Limite: Animals Idioma: En Revista: Neuropharmacology Ano de publicação: 2000 Tipo de documento: Article País de afiliação: Coréia do Sul

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