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CD40-ligand stimulates myelopoiesis by regulating flt3-ligand and thrombopoietin production in bone marrow stromal cells.
Solanilla, A; Déchanet, J; El Andaloussi, A; Dupouy, M; Godard, F; Chabrol, J; Charbord, P; Reiffers, J; Nurden, A T; Weksler, B; Moreau, J F; Ripoche, J.
Afiliação
  • Solanilla A; FR 60, Biologie des Greffes, Université de Bordeaux 2; ETS Franche Comté, Besançon, France.
Blood ; 95(12): 3758-64, 2000 Jun 15.
Article em En | MEDLINE | ID: mdl-10845907
CD40 ligand (CD40L)/CD40 interactions play a central role in T-cell-dependent B-cell activation as previously shown by in vitro studies, the phenotype of CD40L knockout mice and the defective expression of CD40L in patients who have X-linked immunodeficiency with hyper-IgM. The distribution of CD40 in cells other than of myeloid and lymphoid lineages has suggested additional functions for this receptor/ligand couple. Here we show that CD40L stimulates myelopoiesis with a noticeable effect on megakaryocytopoiesis in cocultures of hematopoietic progenitor cells and bone marrow stromal cells. These results suggest a mechanism by which T-cell or platelet-associated or soluble CD40L may regulate myelopoiesis. (Blood. 2000;95:3758-3764)
Assuntos
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Base de dados: MEDLINE Assunto principal: Trombopoetina / Células-Tronco Hematopoéticas / Endotélio Vascular / Glicoproteínas de Membrana / Leucopoese / Proteínas de Membrana Limite: Animals / Female / Humans / Newborn / Pregnancy Idioma: En Revista: Blood Ano de publicação: 2000 Tipo de documento: Article País de afiliação: França
Buscar no Google
Base de dados: MEDLINE Assunto principal: Trombopoetina / Células-Tronco Hematopoéticas / Endotélio Vascular / Glicoproteínas de Membrana / Leucopoese / Proteínas de Membrana Limite: Animals / Female / Humans / Newborn / Pregnancy Idioma: En Revista: Blood Ano de publicação: 2000 Tipo de documento: Article País de afiliação: França