Peripheral modulation of rat knee joint afferent mechanosensitivity by nociceptin/orphanin FQ.
Neurosci Lett
; 288(2): 123-6, 2000 Jul 14.
Article
em En
| MEDLINE
| ID: mdl-10876076
ABSTRACT
The peripheral effects of nociceptin were examined in normal and acutely inflamed rat knee joints by analyzing single unit recordings from articular primary afferents in response to normal and extreme rotation of the knee. Bolus close intraarterial injection of nociceptin (0.01, 1 and 100 microM) caused a sensitization of normal and inflamed knee joint afferents in response to movements in the normal working range of the joint. When the joint was hyper-rotated, nociceptin had no significant effect on afferent discharge rate in normal knees, however, in inflamed joints the top dose of the neuropeptide caused a decrease in articular mechanosensitivity. These findings suggest that nociceptin seems to be involved in the control of peripheral nociceptive mechanisms, although the behaviour of the peptide is dependent upon the inflammatory status of the tissue.
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Base de dados:
MEDLINE
Assunto principal:
Receptores Opioides
/
Peptídeos Opioides
/
Aminoácidos Excitatórios
/
Articulação do Joelho
/
Mecanorreceptores
/
Neurônios Aferentes
Limite:
Animals
Idioma:
En
Revista:
Neurosci Lett
Ano de publicação:
2000
Tipo de documento:
Article
País de afiliação:
Canadá