The Dlk1 and Gtl2 genes are linked and reciprocally imprinted.
Genes Dev
; 14(16): 1997-2002, 2000 Aug 15.
Article
em En
| MEDLINE
| ID: mdl-10950864
ABSTRACT
Genes subject to genomic imprinting exist in large chromosomal domains, probably reflecting coordinate regulation of the genes within a cluster. Such regulation has been demonstrated for the H19, Igf2, and Ins2 genes that share a bifunctional imprinting control region. We have identified the Dlk1 gene as a new imprinted gene that is paternally expressed. Furthermore, we show that Dlk1 is tightly linked to the maternally expressed Gtl2 gene. Dlk1 and Gtl2 are coexpressed and respond in a reciprocal manner to loss of DNA methylation. These genes are likely to represent a new example of coordinated imprinting of linked genes.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Impressão Genômica
/
Ligação Genética
Limite:
Animals
Idioma:
En
Revista:
Genes Dev
Assunto da revista:
BIOLOGIA MOLECULAR
Ano de publicação:
2000
Tipo de documento:
Article
País de afiliação:
Estados Unidos