ABSTRACT
The factors that control sodium excretion have been the subject of considerable work in recent years. The natriuresis that follows expansion of the extracellular fluid volume is mediated to a large extent by inhibition of tubular sodium reabsorption. Of the several mechanisms proposed to explain this inhibition, considerable interest has followed the suggestion that a humoral substance is released into the blood stream in response to volume expansion. The present article reviews the evidence for and against the existence of such a humoral substance (natriuretic hormone). It also discusses its proposed chemical nature and its possible site of origin in the organism as well as its mode of action.
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Base de dados:
MEDLINE
Assunto principal:
Hormônios
/
Natriurese
Limite:
Animals
Idioma:
En
Revista:
Nephron
Ano de publicação:
1975
Tipo de documento:
Article