Role of Bacillus subtilis SpoIIIE in DNA transport across the mother cell-prespore division septum.
Science
; 290(5493): 995-7, 2000 Nov 03.
Article
em En
| MEDLINE
| ID: mdl-11062134
ABSTRACT
The SpoIIIE protein of Bacillus subtilis is required for chromosome segregation during spore formation. The COOH-terminal cytoplasmic part of SpoIIIE was shown to be a DNA-dependent adenosine triphosphatase (ATPase) capable of tracking along DNA in the presence of ATP, and the NH(2)-terminal part of the protein was found to mediate its localization to the division septum. Thus, during sporulation, SpoIIIE appears to act as a DNA pump that actively moves one of the replicated pair of chromosomes into the prespore. The presence of SpoIIIE homologs in a broad range of bacteria suggests that this mechanism for active transport of DNA may be widespread.
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Base de dados:
MEDLINE
Assunto principal:
Fator sigma
/
Bacillus subtilis
/
Proteínas de Bactérias
/
Fatores de Transcrição
/
DNA Bacteriano
/
Adenosina Trifosfatases
/
DNA Helicases
Idioma:
En
Revista:
Science
Ano de publicação:
2000
Tipo de documento:
Article
País de afiliação:
Estados Unidos