Chromatin proteins from human lymphocytes: a gel electrophoretic comparison between normal, mitogen-stimulated, cell-line, and chronic lymphocytic leukemia lymphocytes.
J Natl Cancer Inst
; 54(1): 37-48, 1975 Jan.
Article
em En
| MEDLINE
| ID: mdl-1113311
ABSTRACT
Cell-line lymphocytes contained considerably more nonhistone chromatin protein than normal lymphocytes. The overall electrophoretic pattern of the nonhistone chromatin proteins from nonreplicating cell types with predominantly condensed chromatin (normal lymphocytes and chronic lymphocytic leukemia lymphocytes) was similar, as it was between replicating cell types with predominantly decondensed chromatin (mitogen-stimulated normal lymphocytes and cell-line lymphocytes), although all four cell types differed qualitatively. A "heavy" chromatin fraction from cell-line lymphocytes could be distinguished from a "light" fraction and had a pattern similar to that from cells of the condensed chromatin type. Normal lymphocytes contained two acid-soluble chromatin polypeptieds not found in cell-line lymphocytes.
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Base de dados:
MEDLINE
Assunto principal:
Cromatina
/
Ativação Linfocitária
/
Linfócitos
/
Leucemia Linfoide
/
Proteínas
/
Concanavalina A
/
Proteínas de Neoplasias
Limite:
Humans
Idioma:
En
Revista:
J Natl Cancer Inst
Ano de publicação:
1975
Tipo de documento:
Article