Gene expression of angiogenesis related factors in glioma.
Int J Oncol
; 18(2): 305-9, 2001 Feb.
Article
em En
| MEDLINE
| ID: mdl-11172596
ABSTRACT
Angiogenesis plays an important role in growth and proliferation of cancer. Various angiogenic and angiostatic factors regulate angiogenesis. In this study, we examined gene expression of the angiopoietin family including angiopoietin 1 (Ang1) and angiopoietin 2 (Ang2) in 39 gliomas and 5 glioma-xenografts by RT-PCR. Ang1 and Ang2 genes were expressed in 54%, and 77% of gliomas, respectively. The expression of Ang1 was significantly correlated with the expression of Ang2. Both Ang1 and Ang2 were shown to be expressed in the glioma cells. Ang2 gene expression was correlated with VEGF gene expression. Angiopoietin molecules may synergistically cooperate in growth and vascularization in glioma.
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Base de dados:
MEDLINE
Assunto principal:
Glicoproteínas de Membrana
/
Proteínas
/
Expressão Gênica
/
Proteínas Proto-Oncogênicas
/
Glioma
/
Proteínas de Neoplasias
/
Neovascularização Patológica
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Int J Oncol
Assunto da revista:
NEOPLASIAS
Ano de publicação:
2001
Tipo de documento:
Article
País de afiliação:
Japão