Specific function of B-Raf in mediating survival of embryonic motoneurons and sensory neurons.
Nat Neurosci
; 4(2): 137-42, 2001 Feb.
Article
em En
| MEDLINE
| ID: mdl-11175873
ABSTRACT
Embryonic sensory and motoneurons depend on neurotrophic factors for survival. Here we show that their survival requires B-Raf, which, in this function, cannot be substituted by C-Raf. Sensory and motoneurons from b-raf-deficient mice do not respond to neurotrophic factors for their survival. However, these primary neurons can be rescued by transfection of a b-raf expression plasmid. In contrast, c-raf-deficient neurons survive in response to neurotrophic factors, similarly to neurons from wild-type mice. This points to an essential and specific function of B-Raf in mediating survival of sensory and motoneurons during development.
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Base de dados:
MEDLINE
Assunto principal:
Medula Espinal
/
Proteínas Proto-Oncogênicas c-raf
/
Gânglios Espinais
/
Neurônios Motores
/
Neurônios Aferentes
Limite:
Animals
Idioma:
En
Revista:
Nat Neurosci
Assunto da revista:
NEUROLOGIA
Ano de publicação:
2001
Tipo de documento:
Article
País de afiliação:
Alemanha