Hibernated human fetal striatal tissue: successful transplantation in a rat model of Huntington's disease.
Cell Transplant
; 9(6): 743-9, 2000.
Article
em En
| MEDLINE
| ID: mdl-11202561
ABSTRACT
The use of fresh human fetal tissue in neural transplantation presents considerable logistical difficulties and limits the clinical applicability of this promising therapy. This study compared the survival of human fetal striatal tissue that had been stored for 24 h in a defined hibernation medium with that of fresh human fetal striatal tissue following xenotransplantation in a rat model of Huntington's disease (HD). Six to 7 weeks postgrafting, there was no significant difference between fresh and hibernated grafts in volume or in various striatal phenotypic markers, although there was a trend towards decreased graft volume. We conclude that short-term hibernation of this tissue is without significant adverse effects on the survival of grafted human fetal striatal tissue. This has important implications for the practical implementation of clinical neural transplant programs in HD.
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Base de dados:
MEDLINE
Assunto principal:
Preservação de Tecido
/
Transplante de Tecido Encefálico
/
Transplante de Tecido Fetal
/
Doença de Huntington
/
Corpo Estriado
/
Proteínas do Tecido Nervoso
/
Neurônios
Limite:
Animals
/
Female
/
Humans
Idioma:
En
Revista:
Cell Transplant
Assunto da revista:
TRANSPLANTE
Ano de publicação:
2000
Tipo de documento:
Article
País de afiliação:
Reino Unido