Long-term potentiation induced by nicotine in CA1 region of hippocampal slice is Ca(2+)-dependent.
Acta Pharmacol Sin
; 21(5): 429-32, 2000 May.
Article
em En
| MEDLINE
| ID: mdl-11324441
ABSTRACT
AIM:
To observe the effects of Ca2+ on hippocampal long-term potentiation (LTP) induced by nicotine in CA1 region of rat hippocampal slice.METHODS:
Extracellularly recorded population spikes (PS) of the pyramidal cell layer in the hippocampal CA1 region in vitro.RESULTS:
Nicotine 1 mumol.L-1 induced LTP in the hippocampal CA1 region. It did not induce LTP in CA1 region when CA2+ was removed from artificial cerebrospinal fluid (ACSF). Nifedipine 1 and 10 mumol.L-1 partly inhibited LTP induced by nicotine, and thapsigargin 1 and 10 mumol.L-1 completely inhibited LTP induced by nicotine.CONCLUSION:
LTP induced by nicotine in hippocampal CA1 region is Ca(2+)-dependent. Both Ca2+ influx and Ca2+ release participate in the induction of LTP.
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Base de dados:
MEDLINE
Assunto principal:
Bloqueadores dos Canais de Cálcio
/
Nifedipino
/
Potenciação de Longa Duração
/
Tapsigargina
/
Hipocampo
Limite:
Animals
Idioma:
En
Revista:
Acta Pharmacol Sin
Assunto da revista:
FARMACOLOGIA
Ano de publicação:
2000
Tipo de documento:
Article
País de afiliação:
China