Citalopram versus nortriptyline in late-life depression: a 12-week randomized single-blind study.
Acta Psychiatr Scand
; 103(6): 435-40, 2001 Jun.
Article
em En
| MEDLINE
| ID: mdl-11401657
ABSTRACT
OBJECTIVE:
The aim of this single-blind study was to examine the efficacy and tolerability of citalopram compared to nortriptyline in moderate to severe major depressive patients aged 60 years or over.METHOD:
In- and out-patients (N=58) with unipolar major depression were randomized to 12-week flexible dose treatment with nortriptyline or citalopram.RESULTS:
No significant differences between the number of drop-outs in either group were observed, but the autonomic side-effects were significantly higher for nortriptyline than for citalopram. A significantly higher remission rate to nortriptyline than to citalopram was demonstrated, particularly if severe patients (endogenous or psychotic patients) were assessed.CONCLUSION:
The remission rate to a therapeutic plasma level of nortriptyline appears to be higher than the remission rate to a standard dose of citalopram in a group of elderly major depressed patients, especially those with endogenous or psychotic features. On the other hand, citalopram appears to be better tolerated.
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Base de dados:
MEDLINE
Assunto principal:
Citalopram
/
Antidepressivos de Segunda Geração
/
Transtorno Depressivo
/
Antidepressivos Tricíclicos
/
Nortriptilina
Tipo de estudo:
Clinical_trials
Limite:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Acta Psychiatr Scand
Ano de publicação:
2001
Tipo de documento:
Article
País de afiliação:
Espanha