Hyperexcitability in sensory neurons of rats selected for high versus low neuropathic pain phenotype.
Neuroscience
; 105(1): 265-75, 2001.
Article
em En
| MEDLINE
| ID: mdl-11483317
ABSTRACT
Selection line rats congenitally high or low for autotomy in the neuroma model of neuropathic pain (HA and LA rats) were found to be correspondingly high and low in a second type of neuropathic pain, the Chung model, which employs an alternative phenotypic endpoint, tactile allodynia. It has been proposed that both phenotypes reflect ectopic hyperexcitability in axotomized primary sensory neurons. To test this hypothesis we made in vitro recordings from sensory neurons in the L4 and 5 dorsal root ganglia. Baseline excitability was similar in HA and LA rats, and axotomy caused an increase in both lines. However, in the one neuronal subclass previously linked to neuropathic pain in these models the increase was significantly greater in HA than LA rats, and only at the time when pain scores in the two lines were diverging. Heritable differences in electrical response to axotomy in a specific afferent cell type appear to be a fundamental determinant of neuropathic pain.
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Base de dados:
MEDLINE
Assunto principal:
Potenciais de Ação
/
Doenças do Sistema Nervoso Periférico
/
Gânglios Espinais
/
Hiperalgesia
/
Neuralgia
/
Neurônios Aferentes
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
Neuroscience
Ano de publicação:
2001
Tipo de documento:
Article
País de afiliação:
Israel