Lipopolyamines as a therapeutic strategy in experimental Gram-negative bacterial sepsis.
J Endotoxin Res
; 7(1): 35-8, 2001.
Article
em En
| MEDLINE
| ID: mdl-11521079
ABSTRACT
Lipopolyamines are a class of polycationic amphiphilic compounds that have been shown to bind with high affinity to polyanionic macromolecules, including both DNA and bacterial lipopoly-saccharide (LPS). One of these compounds, termed DOSPER (1,3-di-oleoyloxy-2-(6-carboxyl-spermyl)- propylamide), is non-cytotoxic and has been shown to inhibit LPS-mediated cytokine release and lethality in endotoxin challenge models. In the study reported here, the activity of DOSPER was tested in neutropenic rats with invasive Gram-negative bacteremia caused by Pseudomonas aeruginosa. DOSPER alone was ineffective (0/8) at influencing mortality, but provided a significant survival advantage if administered in combination with a bactericidal antibiotic, ceftazidime (10/12; P<0.05). Ceftazidime alone was partially protective (6/12) while the control group had no survivors (0/8). DOSPER administration markedly reduced circulating endotoxin levels (P<0.01) and interleukin-6 levels (P<0.05) but had no significant effect on bacteremia and bacterial concentrations of P. aeruginosa in liver or spleen tissue. Lipopolyamines may be potentially valuable as a therapeutic adjunct in treatment of Gram-negative bacterial sepsis.
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Base de dados:
MEDLINE
Assunto principal:
Ácidos Graxos Monoinsaturados
/
Ceftazidima
/
Cefalosporinas
/
Infecções por Bactérias Gram-Negativas
/
Sepse
Limite:
Animals
Idioma:
En
Revista:
J Endotoxin Res
Assunto da revista:
ANGIOLOGIA
/
BACTERIOLOGIA
Ano de publicação:
2001
Tipo de documento:
Article
País de afiliação:
Estados Unidos