Anoikis mechanisms.
Curr Opin Cell Biol
; 13(5): 555-62, 2001 Oct.
Article
em En
| MEDLINE
| ID: mdl-11544023
ABSTRACT
Anoikis is defined as apoptosis that is induced by inadequate or inappropriate cell-matrix interactions. It is involved in a wide diversity of tissue-homeostatic, developmental and oncogenic processes. The central problem of anoikis is to understand how integrin-mediated cell adhesion signals control the apoptotic machinery. In particular, the initiation of the caspase cascade in anoikis remains to be explained.
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Base de dados:
MEDLINE
Assunto principal:
Integrinas
/
Proteínas Serina-Treonina Quinases
/
Anoikis
/
Proteínas Adaptadoras de Transdução de Sinal
Limite:
Humans
Idioma:
En
Revista:
Curr Opin Cell Biol
Ano de publicação:
2001
Tipo de documento:
Article
País de afiliação:
Estados Unidos