Frizzled signaling and cell-cell interactions in planar polarity.
Curr Opin Cell Biol
; 13(5): 635-40, 2001 Oct.
Article
em En
| MEDLINE
| ID: mdl-11544034
ABSTRACT
The function of the Frizzled pathway is essential for the formation of the array of distally pointing hairs found on the Drosophila wing. Previous research found that regulating the subcellular location for hair initiation controlled hair polarity. Recent work argues a graded Frizzled-dependent signal results in the accumulation of the Frizzled, Dishevelled and Flamingo proteins along the distal edge of the wing cells. This cortical mark leads to the local activation of downstream gene products and the subsequent activation of the cytoskeleton to form a hair.
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Base de dados:
MEDLINE
Assunto principal:
Asas de Animais
/
Padronização Corporal
/
Proteínas de Drosophila
/
Drosophila
/
Cabelo
/
Proteínas de Membrana
Limite:
Animals
Idioma:
En
Revista:
Curr Opin Cell Biol
Ano de publicação:
2001
Tipo de documento:
Article
País de afiliação:
Estados Unidos