Angiopoietin and Tie signaling pathways in vascular development.
Matrix Biol
; 20(5-6): 319-25, 2001 Sep.
Article
em En
| MEDLINE
| ID: mdl-11566266
ABSTRACT
The angiopoietin ligands and Tie receptors belong to a novel class of ligand/receptor families, which play critical roles in blood vessel formation. They are considered to control numerous signaling pathways that are involved in diverse cellular processes, such as cell migration, proliferation and survival, and reorganization of the actin cytoskeleton. In this review, we summarize the important biochemical and biological properties of this interesting ligand/receptor family. Particular emphasis will be made on potential downstream targets and consequences of the endothelial cell behavior, due to regulation by the angiopoietin/Tie pathway.
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Base de dados:
MEDLINE
Assunto principal:
Vasos Sanguíneos
/
Glicoproteínas de Membrana
/
Proteínas
/
Proteínas Proto-Oncogênicas
/
Proteínas de Neoplasias
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Matrix Biol
Assunto da revista:
BIOLOGIA MOLECULAR
/
BIOQUIMICA
Ano de publicação:
2001
Tipo de documento:
Article
País de afiliação:
Estados Unidos