A phosphatase associated with metastasis of colorectal cancer.
Science
; 294(5545): 1343-6, 2001 Nov 09.
Article
em En
| MEDLINE
| ID: mdl-11598267
ABSTRACT
To gain insights into the molecular basis for metastasis, we compared the global gene expression profile of metastatic colorectal cancer with that of primary cancers, benign colorectal tumors, and normal colorectal epithelium. Among the genes identified, the PRL-3 protein tyrosine phosphatase gene was of particular interest. It was expressed at high levels in each of 18 cancer metastases studied but at lower levels in nonmetastatic tumors and normal colorectal epithelium. In 3 of 12 metastases examined, multiple copies of the PRL-3 gene were found within a small amplicon located at chromosome 8q24.3. These data suggest that the PRL-3 gene is important for colorectal cancer metastasis and provide a new therapeutic target for these intractable lesions.
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Base de dados:
MEDLINE
Assunto principal:
Neoplasias Colorretais
/
Proteínas Tirosina Fosfatases
/
Proteínas Imediatamente Precoces
/
Metástase Neoplásica
Tipo de estudo:
Risk_factors_studies
Limite:
Humans
Idioma:
En
Revista:
Science
Ano de publicação:
2001
Tipo de documento:
Article
País de afiliação:
Estados Unidos