p38-Dependent marking of inflammatory genes for increased NF-kappa B recruitment.
Nat Immunol
; 3(1): 69-75, 2002 Jan.
Article
em En
| MEDLINE
| ID: mdl-11743587
ABSTRACT
We found that inflammatory stimuli induce p38 mitogen-activated protein kinase-dependent phosphorylation and phosphoacetylation of histone H3; this selectively occurred on the promoters of a subset of stimulus-induced cytokine and chemokine genes. p38 activity was required to enhance the accessibility of the cryptic NF-kappa B binding sites contained in H3 phosphorylated promoters, which indicated that p38-dependent H3 phosphorylation may mark promoters for increased NF-kappa B recruitment. These results show that p38 plays an additional role in the induction of the inflammatory and immune response the regulation of NF-kappa B recruitment to selected chromatin targets.
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Base de dados:
MEDLINE
Assunto principal:
Células Dendríticas
/
Cromatina
/
Histonas
/
Processamento de Proteína Pós-Traducional
/
Regulação da Expressão Gênica
/
Interleucina-8
/
NF-kappa B
/
Regiões Promotoras Genéticas
/
Protamina Quinase
/
Quimiocina CCL2
Tipo de estudo:
Prognostic_studies
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Nat Immunol
Assunto da revista:
ALERGIA E IMUNOLOGIA
Ano de publicação:
2002
Tipo de documento:
Article
País de afiliação:
Suíça