A gene-driven approach to the identification of ENU mutants in the mouse.
Nat Genet
; 30(3): 255-6, 2002 Mar.
Article
em En
| MEDLINE
| ID: mdl-11850622
ABSTRACT
The construction of parallel archives of DNA and sperm from mice mutagenized with ethylnitrosurea (ENU) represents a potentially powerful and rapid approach for identifying point mutations in any gene in the mouse genome. We provide support for this approach and report the identification of mutations in the gene (Gjb2) encoding connexin 26, using archives established from the UK ENU mutagenesis program.
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Base de dados:
MEDLINE
Assunto principal:
Etilnitrosoureia
/
Mutagênicos
/
Mutação
Tipo de estudo:
Diagnostic_studies
Limite:
Animals
Idioma:
En
Revista:
Nat Genet
Assunto da revista:
GENETICA MEDICA
Ano de publicação:
2002
Tipo de documento:
Article
País de afiliação:
Reino Unido