Autoimmune thyroid disease: new models of cell death in autoimmunity.
Nat Rev Immunol
; 2(3): 195-204, 2002 Mar.
Article
em En
| MEDLINE
| ID: mdl-11913070
ABSTRACT
Autoimmunity to thyroid antigens leads to two distinct pathogenic processes with opposing clinical outcomes:
hypothyroidism in Hashimoto's thyroiditis and hyperthyroidism in Graves' disease. The high frequency of these diseases and easy accessibility of the thyroid gland has allowed the identification of key pathogenic mechanisms in organ-specific autoimmune diseases. In early investigations, antibody- and T-cell-mediated death mechanisms were proposed as being responsible for autoimmune thyrocyte depletion. Later, studies on apoptosis have provided new insights into autoimmune target destruction, indicating the involvement of death receptors and cytokine-regulated apoptotic pathways in the pathogenesis of thyroid autoimmunity.
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Base de dados:
MEDLINE
Assunto principal:
Glândula Tireoide
/
Tireoidite Autoimune
/
Autoimunidade
/
Doença de Graves
/
Apoptose
Tipo de estudo:
Prognostic_studies
Limite:
Humans
Idioma:
En
Revista:
Nat Rev Immunol
Assunto da revista:
ALERGIA E IMUNOLOGIA
Ano de publicação:
2002
Tipo de documento:
Article
País de afiliação:
Itália