Retention of nonhelical procollagen containing cis-hydroxyproline in rough endoplasmic reticulum.
Science
; 190(4220): 1202-4, 1975 Dec 19.
Article
em En
| MEDLINE
| ID: mdl-1198105
ABSTRACT
Fibroblasts freshly isolated from embryonic tendons were incubated with a proline analog, cis-4-hydroxy-L-proline, which is incorporated into protein and which leads to the intracellular accumulation of nonhelical procollagen. Evidence is presented here that the nonhelical procollagen containing the analog is retained within the rough endoplasmic reticulum and does not pass to the smooth endoplasmic reticulum or Golgi vacuoles at a normal rate.
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Base de dados:
MEDLINE
Assunto principal:
Precursores de Proteínas
/
Colágeno
/
Retículo Endoplasmático
Limite:
Animals
Idioma:
En
Revista:
Science
Ano de publicação:
1975
Tipo de documento:
Article