Changes in peritoneal coagulation and fibrinolysis after discontinuation of chronic peritoneal dialysis.
Perit Dial Int
; 22(2): 178-83, 2002.
Article
em En
| MEDLINE
| ID: mdl-11990401
ABSTRACT
OBJECTIVES:
To study changes in peritoneal function after transfer from chronic peritoneal dialysis (CPD) to hemodialysis (HD), especially the effects on peritoneal coagulation, fibrinolytic markers, and mesothelium.DESIGN:
Prospective observational study.SETTING:
A tertiary-care university hospital. PATIENTS Nine patients who transferred from CPD to HD were enrolled in the study after giving fully informed consent.METHODS:
After transfer to HD, the peritoneal cavity was lavaged with low glucose PD solution once per day through PD catheters left in place. Thrombin-antithrombin III complex (TAT) was measured serially as a marker of peritoneal coagulation. As fibrinolytic markers, fibrinogen/fibrin degradation products (FDP) and plasmin-alpha2-antiplasmin complex (PIC) were assessed. Cancer antigen 125 (CA125) was measured as a marker of mesothelial cell mass.RESULTS:
Levels of peritoneal TAT and FDP were much higher than plasma levels, indicating high local fibrin turnover. Transfer to HD induced a significant fall in mean peritoneal TAT, from 115.8 +/- 52.1 to 60.7 +/- 21.8 ng/mL, p < 0.05. Except for 1 patient with a 20-fold increase, mean peritoneal FDP decreased significantly, from 43.6 +/- 11.1 to 19.6 +/- 3.5 microg/mL, p < 0.05. Mean peritoneal PIC increased significantly, from 1.9 +/- 0.4 to 3.9 +/- 0.6 microg/mL, p < 0.05. Peritoneal CA125 increased from 156.4 +/- 57.3 to 1426.2 +/- 389.4 U/mL, p < 0.05.CONCLUSIONS:
Peritoneal fibrin turnover was accelerated on CPD and stabilized after transfer to HD. Transfer to HD also induced mesothelial regeneration.
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Base de dados:
MEDLINE
Assunto principal:
Peritônio
/
Coagulação Sanguínea
/
Diálise Peritoneal
/
Fibrinólise
Tipo de estudo:
Observational_studies
Limite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Perit Dial Int
Assunto da revista:
NEFROLOGIA
Ano de publicação:
2002
Tipo de documento:
Article
País de afiliação:
Japão