The quest for an AIDS vaccine: is the CD8+ T-cell approach feasible?
Nat Rev Immunol
; 2(4): 283-91, 2002 Apr.
Article
em En
| MEDLINE
| ID: mdl-12001999
ABSTRACT
The rationale for developing anti-HIV vaccines that stimulate cytotoxic T-lymphocyte responses is given. We argue that such vaccines will work, provided that attention is paid to the development of memory T-cell responses that are strong and preferably activated. Furthermore, the vaccine should match the prevailing virus clade as closely as possible. Vaccines will have to stimulate a wide range of responses, but it is not clear how this can be achieved.
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Base de dados:
MEDLINE
Assunto principal:
Síndrome da Imunodeficiência Adquirida
/
HIV
/
Vacinas contra a AIDS
/
Linfócitos T CD8-Positivos
/
Citotoxicidade Imunológica
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Nat Rev Immunol
Assunto da revista:
ALERGIA E IMUNOLOGIA
Ano de publicação:
2002
Tipo de documento:
Article
País de afiliação:
Reino Unido