Increased autoantibodies to SOX13 in Swedish patients with type 1 diabetes.
Ann N Y Acad Sci
; 958: 218-23, 2002 Apr.
Article
em En
| MEDLINE
| ID: mdl-12021110
ABSTRACT
This article aims to estimate the prevalence of SOX13 antibodies in Swedish patients with type 1 diabetes and healthy controls. The patients (n = 102; median age 35 years [range, 9-89]) were newly diagnosed with type 1 diabetes in a defined area in southern Sweden during 1995-1998. Islet cell antibodies (ICA) were analyzed with immunofluorescence, while glutamic acid decarboxylase antibodies (GADA), tyrosine phosphatase antibodies (IA-2A), and antibodies against the transcription factor SOX13 (SOX13Ab) were analyzed with radioimmunoprecipitating assays. SOX13Ab were found in 9.8% (10/102) of type 1 patients compared to 2.0% (2/99) in healthy controls (P = 0.033). At least one of the four autoantibodies (ICA, GADA, IA-2A or SOX13Ab) were identified in 67% (68/102) of the patients. Samples positive for IA-2A were only in one case positive also for SOX13Ab. IA-2A-positive patients were often positive also for ICA and GADA (19/27), and the same combination was also common for SOX13Ab-positive patients (6/10). Only 2.0% (2/102) were positive for SOX13Ab alone. ICA, GADA and IA-2A were more frequent in younger patients (
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Autoanticorpos
/
Autoantígenos
/
Proteínas de Grupo de Alta Mobilidade
/
Diabetes Mellitus Tipo 1
Tipo de estudo:
Prognostic_studies
/
Risk_factors_studies
Limite:
Adolescent
/
Adult
/
Aged
/
Aged80
/
Child
/
Humans
/
Middle aged
País/Região como assunto:
Europa
Idioma:
En
Revista:
Ann N Y Acad Sci
Ano de publicação:
2002
Tipo de documento:
Article
País de afiliação:
Suécia