Dopaminergic cells of the carotid body: physiological significance and possible therapeutic applications in Parkinson's disease.
Brain Res Bull
; 57(6): 847-53, 2002 Apr.
Article
em En
| MEDLINE
| ID: mdl-12031283
ABSTRACT
Parkinson's disease is a neurodegenerative disorder characterized by the progressive loss of dopaminergic neurons in the substantia nigra projecting to the striatum. One therapeutic approach to this disease has been the intrastriatal transplantation of dopamine-secreting cells. We have investigated the suitability of glomus cells of the carotid body for dopamine-cell replacement in animal models of Parkinson's disease. Carotid body glomus cells are physiologic arterial oxygen sensors that release large amounts of dopamine in response to hypoxia. We have used hemi-Parkinsonian rats, induced by injection of 6-hydroxydopamine into the substantia nigra, and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine treated monkeys with chronic Parkinsonism. In both cases we made transplants of carotid body cell aggregates into the putamen. Functional recovery of the grafted animals was observed after the surgery and was stable for several months. Although the study was more detailed in the rat, in the two animal models the amelioration of the motor deficits was paralleled by striatal dopaminergic reinnervation and survival of grafted glomus cells. Our results suggest that intrastriatal autotransplants of carotid body tissue could be a feasible technique to treat some cases of Parkinson's disease in humans.
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Base de dados:
MEDLINE
Assunto principal:
Corpo Carotídeo
/
Dopamina
/
Transplante de Tecido Encefálico
/
Neostriado
/
Transtornos Parkinsonianos
/
Neurônios
Tipo de estudo:
Prognostic_studies
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Brain Res Bull
Ano de publicação:
2002
Tipo de documento:
Article
País de afiliação:
Espanha