The VPAC(2) receptor is essential for circadian function in the mouse suprachiasmatic nuclei.
Cell
; 109(4): 497-508, 2002 May 17.
Article
em En
| MEDLINE
| ID: mdl-12086606
ABSTRACT
The neuropeptides pituitary adenylate cyclase-activating polypeptide (PACAP) and vasoactive intestinal peptide (VIP) are implicated in the photic entrainment of circadian rhythms in the suprachiasmatic nuclei (SCN). We now report that mice carrying a null mutation of the VPAC(2) receptor for VIP and PACAP (Vipr2(-/-)) are incapable of sustaining normal circadian rhythms of rest/activity behavior. These mice also fail to exhibit circadian expression of the core clock genes mPer1, mPer2, and mCry1 and the clock-controlled gene arginine vasopressin (AVP) in the SCN. Moreover, the mutants fail to show acute induction of mPer1 and mPer2 by nocturnal illumination. This study highlights the role of intercellular neuropeptidergic signaling in maintenance of circadian function within the SCN.
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Base de dados:
MEDLINE
Assunto principal:
Núcleo Supraquiasmático
/
Neuropeptídeos
/
Peptídeo Intestinal Vasoativo
/
Regulação da Expressão Gênica
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Ritmo Circadiano
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Receptores de Peptídeo Intestinal Vasoativo
/
Células Fotorreceptoras de Invertebrados
/
Proteínas de Drosophila
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Proteínas do Olho
/
Neurônios
Limite:
Animals
Idioma:
En
Revista:
Cell
Ano de publicação:
2002
Tipo de documento:
Article
País de afiliação:
Reino Unido