Conversion of cerebral cortex into basal ganglia in Emx2(-/-) Pax6(Sey/Sey) double-mutant mice.
Nat Neurosci
; 5(8): 737-45, 2002 Aug.
Article
em En
| MEDLINE
| ID: mdl-12118260
ABSTRACT
The molecular mechanisms that activate morphogenesis of cerebral cortex are currently the subject of intensive experimental analysis. Transcription factor genes of the homeobox, basic helix-loop-helix (bHLH) and zinc-finger families have recently been shown to have essential roles in this process. However, the actual selector genes activating corticogenesis have not yet been identified. Here we show that high-level expression of at least one functional allele of either of the homeobox genes Emx2 or Pax6 in the dorsal telencephalon is necessary and sufficient to stably activate morphogenesis of cerebral cortex and to repress that of adjacent structures, such as striatum.
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Base de dados:
MEDLINE
Assunto principal:
Gânglios da Base
/
Córtex Cerebral
/
Proteínas de Homeodomínio
/
Malformações do Sistema Nervoso
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
Nat Neurosci
Assunto da revista:
NEUROLOGIA
Ano de publicação:
2002
Tipo de documento:
Article
País de afiliação:
Itália