Genetic association between interleukin-10 gene promoter region polymorphisms and type 1 diabetes age-at-onset.
Hum Immunol
; 63(8): 690-5, 2002 Aug.
Article
em En
| MEDLINE
| ID: mdl-12121678
ABSTRACT
This study investigated whether interleukin-10 (IL-10) gene promoter region polymorphisms are associated with susceptibility to or clinical presentation of type 1 diabetes. The frequency of -1082G/A, -819C/T, and -592C/A polymorphisms was analyzed in 128 Japanese patients with type 1 diabetes and in 107 healthy control subjects in a case-controlled study. The allelic and haplotypic frequencies of the IL-10 gene promoter region polymorphisms were similar in patients with type 1 diabetes and in control subjects. However, the -819T and -592A allele were associated with adult-onset (>18 years) of the disease (p = 0.037). Furthermore, the frequency of ATA haplotype was increased in adult-onset patients than that in early-onset patients (< or =18 years; p = 0.037). Among the genotypes comprising ATA haplotype, the frequency of ATA/ATA was significantly higher in adult-onset patients than in early-onset patients (p = 0.004). These results suggest that the IL-10 gene promoter polymorphisms are associated with the age-at-onset in Japanese patients with type 1 diabetes.
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Base de dados:
MEDLINE
Assunto principal:
Polimorfismo Genético
/
Regiões Promotoras Genéticas
/
Interleucina-10
/
Diabetes Mellitus Tipo 1
Tipo de estudo:
Etiology_studies
/
Observational_studies
/
Risk_factors_studies
Limite:
Adolescent
/
Adult
/
Aged
/
Child
/
Child, preschool
/
Female
/
Humans
/
Infant
/
Male
/
Middle aged
País/Região como assunto:
Asia
Idioma:
En
Revista:
Hum Immunol
Ano de publicação:
2002
Tipo de documento:
Article
País de afiliação:
Japão