Dendritic cells, antigen distribution and the initiation of primary immune responses to self and non-self antigens.
Semin Cancer Biol
; 12(4): 301-8, 2002 Aug.
Article
em En
| MEDLINE
| ID: mdl-12147204
ABSTRACT
Immunity or tolerance are determined through the bone marrow-derived, antigen-presenting cells, dendritic cells (DC). Stimulation of lymphocytes by different types of DC, DC at different stages of maturity and DC producing and responding to different growth factors modulate immune responses. Innate receptors for foreign or self antigens provide scope in DC for discrimination between different antigenic stimuli. DC also transfer processed antigens to other DC. We propose that DC do not stimulate responses to antigens in their own environment but only to antigens acquired from other DC, providing a mechanism for discriminating between environmental and non-environmental antigens.
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Base de dados:
MEDLINE
Assunto principal:
Células Dendríticas
/
Tolerância a Antígenos Próprios
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Semin Cancer Biol
Assunto da revista:
NEOPLASIAS
Ano de publicação:
2002
Tipo de documento:
Article
País de afiliação:
Reino Unido