In vitro comparison of activities of terbinafine and itraconazole against Paracoccidioides brasiliensis.
J Clin Microbiol
; 40(8): 2828-31, 2002 Aug.
Article
em En
| MEDLINE
| ID: mdl-12149337
ABSTRACT
In vitro, terbinafine is highly active against a broad spectrum of pathogenic fungi. We evaluated the activities of terbinafine and itraconazole against 31 isolates of Paracoccidioides brasiliensis. The tests were conducted by using a broth macrodilution procedure. MICs, in micrograms per milliliter, were as follows terbinafine, 0.015 to 1.0 (geometric mean, 0.1188); itraconazole, 0.007 to 0.5 (geometric mean, 0.03165). The usual therapy for paracoccidioidomycosis is sulfonamides, amphotericin B, and azole derivatives (ketoconazole, itraconazole, and fluconazole). In comparison to amphotericin B, azole derivatives allow shorter treatment courses, can be administered orally, and are equally effective. Itraconazole has as high efficacy as ketoconazole, but with superior tolerance. It is the current drug of choice for treatment of paracoccidioidomycosis. The data obtained in this study indicate that terbinafine is active against P. brasiliensis in vitro and suggest that this allylamine can be considered a new option as drug therapy for paracoccidioidomycosis.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Paracoccidioides
/
Paracoccidioidomicose
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Itraconazol
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Antifúngicos
/
Naftalenos
Limite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
País/Região como assunto:
America do sul
/
Brasil
Idioma:
En
Revista:
J Clin Microbiol
Ano de publicação:
2002
Tipo de documento:
Article
País de afiliação:
Brasil