[Risk factors for Wilms' tumor development in children]. / Factores de riesgo para el desarrollo de tumor de Wilms en la edad pediátrica.
Gac Med Mex
; 138(4): 301-11, 2002.
Article
em Es
| MEDLINE
| ID: mdl-12200874
ABSTRACT
INTRODUCTION:
Wilms' tumor (WT) is the most frequent embryonic renal neoplasia in children.OBJECTIVE:
This study was carried out to investigate risk factors in the development of WT. MATERIAL ANDMETHODS:
A design of cases and controls, proactive, of incident cases, with four controls per case. The study population of cases were children of two oncologic reference Center of the Mexican Institute of Social Security (IMSS) in the Mexican Federal District during 5-year period. For the control group, children were frequency matched by age and sex at with cases from the same clinic. A questionnaire, previously validated, was applied to determine risk factors in both groups.RESULTS:
During the period of study, 34 cases and 136 controls were revised. Significant risk factors were antecedent of a relative with Down syndrome (OR = 7.6, 95%CI 1.4-51.1, p = 0.008), eczema (OR = 3.7, 95%Cl 1.1-12, p = 0.01); having been conceived in autumn (OR = 5.4, 95%CI 1.3-31.6, p = 0.007) or winter (OR = 4.9, 95%Cl 1.1-29.9, p = 0.01), and beet ingestion (OR = S. 7, 95%Cl 1.7-19.4, p = 0.0007).CONCLUSIONS:
In this study, influence of prenatal factors are shown and we attempt to explain the etiology of WT, the important of beet ingestion, and conclusions suggest that that more epidemiologic studies are necessary to determine the chain of events that causes Wilms' tumor.
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Base de dados:
MEDLINE
Assunto principal:
Tumor de Wilms
Tipo de estudo:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adolescent
/
Child
/
Child, preschool
/
Female
/
Humans
/
Male
País/Região como assunto:
Mexico
Idioma:
Es
Revista:
Gac Med Mex
Ano de publicação:
2002
Tipo de documento:
Article