Mortality benefit of beta-blockade after successful elective percutaneous coronary intervention.
J Am Coll Cardiol
; 40(4): 669-75, 2002 Aug 21.
Article
em En
| MEDLINE
| ID: mdl-12204496
ABSTRACT
OBJECTIVES:
The goal of this study was to evaluate the mortality benefit of beta-blockers after successful percutaneous coronary intervention (PCI).BACKGROUND:
Beta-blockers reduce mortality after myocardial infarction (MI), though limited data are available regarding their role after successful PCI.METHODS:
Each year from 1993 through 1999, the first 1,000 consecutive patients undergoing PCI were systematically followed up. Patients presenting with acute or recent MI, shock, or unsuccessful revascularization procedures were excluded from the analysis. Clinical, procedural, and follow-up data of beta-blocker-treated and non-beta-blocker-treated patients were compared. A multivariate survival analysis model using propensity analysis was used to adjust for heterogeneity between the two groups.RESULTS:
Of the 4,553 patients, 2,056 (45%) were treated with beta-blockers at the time of the procedure. Beta-blocker therapy was associated with a mortality reduction from 1.3% to 0.8% at 30 days (p = 0.13) and a reduction from 6.0% to 3.9% at one year (p = 0.0014). This survival benefit of beta-blockers was independent of left ventricular function, diabetic status, history of hypertension, or history of MI. Using propensity analysis, beta-blocker therapy remained an independent predictor for one-year survival after PCI (hazard ratio, 0.63; 95% confidence interval, 0.46 to 0.87; p = 0.0054).CONCLUSIONS:
Within this large prospective registry, beta-blocker use was associated with a marked long-term survival benefit among patients undergoing successful elective percutaneous coronary revascularization.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Angioplastia Coronária com Balão
/
Antagonistas Adrenérgicos beta
/
Doença das Coronárias
Tipo de estudo:
Evaluation_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
J Am Coll Cardiol
Ano de publicação:
2002
Tipo de documento:
Article
País de afiliação:
Estados Unidos