Comparison of sputum induction using high-output and low-output ultrasonic nebulizers in normal subjects and patients with COPD.
Chest
; 122(3): 955-9, 2002 Sep.
Article
em En
| MEDLINE
| ID: mdl-12226038
ABSTRACT
STUDY OBJECTIVE:
s Induced sputum is used to investigate pulmonary diseases. Low-output ultrasonic nebulizers have become available and have potential advantages over high-output nebulizers. We hypothesized that a low-output nebulizer would give comparable results to a high-output nebulizer, with an acceptable safety profile.DESIGN:
Randomized, crossover study.SETTING:
University teaching hospital.PARTICIPANTS:
Ten normal subjects and 10 patients with COPD.INTERVENTIONS:
Participants attended for sputum induction on two occasions in random order using low-output and high-output nebulizers. MEASUREMENTS ANDRESULTS:
Lung function and oxygen saturation were measured during sputum induction, and tolerability of the procedure was assessed. Cell counts, interleukin 8, and neutrophil elastase were measured in sputum. Use of the high-output nebulizer resulted in a greater FEV(1) (mean +/- SEM, 0.29 +/- 0.04 L vs 0.21 +/- 0.04 L; p = 0.04) and percentage drop in FEV(1) (25.8 +/- 2.6% vs 19.5 +/- 2.9%, respectively; p = 0.02) compared with the low-output nebulizer in patients with COPD. There was a shorter tolerated nebulization time with the high-output nebulizer compared with the low-output nebulizer 12.7 +/- 2.0 min vs 16.5 +/- 1.8 min, respectively (p = 0.02). Modified Borg scores were lower with the low-output nebulizer than the high-output nebulizer in normalsubjects:
median, 0 (interquartile range [IQR], 0 to 1) vs median, 1.5 (IQR, 0 to 2), respectively (p = 0.05). There were no differences in cell counts and soluble markers of inflammation.CONCLUSIONS:
The low-output ultrasonic nebulizer is comparable to high-output nebulizer for cellular and soluble markers of inflammation, results in a smaller reduction in FEV(1), is better tolerated, and is a suitable tool for investigating airway inflammation in patients with COPD.
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Base de dados:
MEDLINE
Assunto principal:
Escarro
/
Nebulizadores e Vaporizadores
/
Doença Pulmonar Obstrutiva Crônica
Tipo de estudo:
Clinical_trials
Limite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Chest
Ano de publicação:
2002
Tipo de documento:
Article