Interleukin 21 is a T helper (Th) cell 2 cytokine that specifically inhibits the differentiation of naive Th cells into interferon gamma-producing Th1 cells.
J Exp Med
; 196(7): 969-77, 2002 Oct 07.
Article
em En
| MEDLINE
| ID: mdl-12370258
ABSTRACT
The cytokine potential of developing T helper (Th) cells is directly shaped both positively and negatively by the cytokines expressed by the effector Th cell subsets. Here we find that the recently identified cytokine, interleukin (IL)-21, is preferentially expressed by Th2 cells when compared with Th1 cells generated in vitro and in vivo. Exposure of naive Th precursors to IL-21 inhibits interferon (IFN)-gamma production from developing Th1 cells. The repression of IFN-gamma production is specific in that the expression of other Th1 and Th2 cytokines is unaffected. IL-21 decreases the IL-12 responsiveness of developing Th cells by specifically reducing both signal transducer and activator of transcription 4 protein and mRNA expression. These results suggest that Th2 cell-derived IL-21 regulates the development of IFN-gamma-producing Th1 cells which could serve to amplify a Th2 response.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Citocinas
/
Interleucinas
/
Interferon gama
/
Linfócitos T Auxiliares-Indutores
/
Células Th1
Limite:
Animals
Idioma:
En
Revista:
J Exp Med
Ano de publicação:
2002
Tipo de documento:
Article
País de afiliação:
Estados Unidos