SB-656104-A: a novel 5-HT(7) receptor antagonist with improved in vivo properties.
Bioorg Med Chem Lett
; 12(22): 3341-4, 2002 Nov 18.
Article
em En
| MEDLINE
| ID: mdl-12392747
ABSTRACT
A focused SAR study around the previously reported selective 5-HT(7) receptor antagonist, SB-269970-A has resulted in the identification of a structurally related analogue having an improved pharmacokinetic profile. Replacement of the phenolic group in SB-269970-A with an indole moiety, and replacement of the piperidinyl 4-methyl group with a heterocyclic ring system proved to be the key changes leading to the identification of SB-656104-A.
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Base de dados:
MEDLINE
Assunto principal:
Fenóis
/
Pirrolidinas
/
Antagonistas da Serotonina
/
Receptores de Serotonina
Limite:
Animals
Idioma:
En
Revista:
Bioorg Med Chem Lett
Assunto da revista:
BIOQUIMICA
/
QUIMICA
Ano de publicação:
2002
Tipo de documento:
Article
País de afiliação:
Reino Unido