Transient Brugada-type electrocardiographic abnormalities in renal failure reversed by dialysis.
Resuscitation
; 55(2): 215-9, 2002 Nov.
Article
em En
| MEDLINE
| ID: mdl-12413761
ABSTRACT
The Brugada syndrome (BRS) is a hereditary cardiac condition (characteristically with a gene mutation affecting sodium channel function) identified by an elevated terminal portion of the QRS complex (prominent J wave) followed by a descending ST-segment elevation ending in a negative T wave in the right precordial leads, and malignant tachyarrhythmias in patients without demonstrable structural heart disease. We report a patient with a previous history of epilepsy treated with psychotropic drugs (with a sodium channel blocking effect) and chronic renal failure on haemodialysis who developed hyperkalaemia (6.6 mmol/l) and ECG findings resembling BRS. This condition was manifested by the prominent J wave, the coved-type ST-segment elevation and the negative T wave in the right precordial leads. These ECG changes disappeared after haemodialysis when the potassium became normal. Subsequently, a flecainide test did not reproduce ST-segment elevation. We conclude that hyperkalaemia associated with cardiac membrane active drugs may cause ECG changes mimicking the Brugada syndrome.
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Base de dados:
MEDLINE
Assunto principal:
Bloqueio de Ramo
/
Eletrocardiografia
/
Epilepsia
/
Hiperpotassemia
/
Falência Renal Crônica
/
Anticonvulsivantes
Tipo de estudo:
Diagnostic_studies
/
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adult
/
Humans
/
Male
Idioma:
En
Revista:
Resuscitation
Ano de publicação:
2002
Tipo de documento:
Article
País de afiliação:
Espanha