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Transient Brugada-type electrocardiographic abnormalities in renal failure reversed by dialysis.
Ortega-Carnicer, Julián; Benezet, Juan; Ruiz-Lorenzo, Francisco; Alcázar, Roberto.
Afiliação
  • Ortega-Carnicer J; Intensive Care Unit and Nephrology Service, Hospital Alarcos, Av Pio XII s/n, 13002 Ciudad Real, Spain. jortegacar@nexo.es
Resuscitation ; 55(2): 215-9, 2002 Nov.
Article em En | MEDLINE | ID: mdl-12413761
ABSTRACT
The Brugada syndrome (BRS) is a hereditary cardiac condition (characteristically with a gene mutation affecting sodium channel function) identified by an elevated terminal portion of the QRS complex (prominent J wave) followed by a descending ST-segment elevation ending in a negative T wave in the right precordial leads, and malignant tachyarrhythmias in patients without demonstrable structural heart disease. We report a patient with a previous history of epilepsy treated with psychotropic drugs (with a sodium channel blocking effect) and chronic renal failure on haemodialysis who developed hyperkalaemia (6.6 mmol/l) and ECG findings resembling BRS. This condition was manifested by the prominent J wave, the coved-type ST-segment elevation and the negative T wave in the right precordial leads. These ECG changes disappeared after haemodialysis when the potassium became normal. Subsequently, a flecainide test did not reproduce ST-segment elevation. We conclude that hyperkalaemia associated with cardiac membrane active drugs may cause ECG changes mimicking the Brugada syndrome.
Assuntos
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Base de dados: MEDLINE Assunto principal: Bloqueio de Ramo / Eletrocardiografia / Epilepsia / Hiperpotassemia / Falência Renal Crônica / Anticonvulsivantes Tipo de estudo: Diagnostic_studies / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Humans / Male Idioma: En Revista: Resuscitation Ano de publicação: 2002 Tipo de documento: Article País de afiliação: Espanha
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Base de dados: MEDLINE Assunto principal: Bloqueio de Ramo / Eletrocardiografia / Epilepsia / Hiperpotassemia / Falência Renal Crônica / Anticonvulsivantes Tipo de estudo: Diagnostic_studies / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Humans / Male Idioma: En Revista: Resuscitation Ano de publicação: 2002 Tipo de documento: Article País de afiliação: Espanha