Type IV secretion and Brucella virulence.
Vet Microbiol
; 90(1-4): 341-8, 2002 Dec 20.
Article
em En
| MEDLINE
| ID: mdl-12414154
The type IV secretion system, encoded by the virB region, is a key virulence factor for Brucella. The 12 genes of the region form an operon that is specifically induced by phagosome acidification in cells after phagocytosis. We speculate that the system serves to secrete unknown effector molecules, which allow Brucella to pervert the host cell endosomal pathways and to create a novel intracellular compartment in which it can replicate.
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Base de dados:
MEDLINE
Assunto principal:
Óperon
/
Brucella
/
Fatores de Virulência
Limite:
Animals
Idioma:
En
Revista:
Vet Microbiol
Ano de publicação:
2002
Tipo de documento:
Article
País de afiliação:
França