[Study on antiplatelet effect of radix astragali total saponin combined with Radix paeoniae rubra glucosides].

OBJECTIVE: To research effects of Radix Astragali total saponin combined with Radix Paeoniae Rubra glucosides (double glucosides of Qi-Shao, DGQS) on antiplatelet. METHODS: Antiplatelet effect of DGQS at three dosages (100 mg/kg, 200 mg/kg, 400 mg/kg) were studied. And levels of granule membrane protein 140 (GMP-140), TXA2 and PGI2 in rat plasma were determined. RESULTS: DGQS as whole could restrain platelet aggregation, decrease content of GMP-140, bring down level of TXA2/PGI2. CONCLUSION: DGQS had apparent antiplatelet effect.