Th2 cell-specific cytokine expression and allergen-induced airway inflammation depend on JunB.
EMBO J
; 21(23): 6321-9, 2002 Dec 02.
Article
em En
| MEDLINE
| ID: mdl-12456639
ABSTRACT
Naïve CD4+ T cells differentiate into effector T helper 1 (Th1) or Th2 cells, which are classified by their specific set of cytokines. Here we demonstrate that loss of JunB in in vitro polarized Th2 cells led to a dysregulated expression of the Th2-specific cytokines IL-4 and IL-5. These cells produce IFN-gamma and express T-bet, the key regulator of Th1 cells. In line with the essential role of Th2 cells in the pathogenesis of allergic asthma, mice with JunB-deficient CD4+ T cells exhibited an impaired allergen-induced airway inflammation. This study demonstrates novel functions of JunB in the development of Th2 effector cells, for a normal Th2 cytokine expression pattern and for a complete Th2-dependent immune response in mice.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Interleucina-4
/
Interleucina-5
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Proteínas Proto-Oncogênicas c-jun
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Células Th2
Limite:
Animals
Idioma:
En
Revista:
EMBO J
Ano de publicação:
2002
Tipo de documento:
Article
País de afiliação:
Alemanha