The TB structural genomics consortium: providing a structural foundation for drug discovery.

Goulding, Celia W; Apostol, Marcin; Anderson, Daniel H; Gill, Harindarpal S; Smith, Clare V; Kuo, Mack R; Yang, Jin Kuk; Waldo, Geoffrey S; Suh, Se Won; Chauhan, Radha; Kale, Avinash; Bachhawat, Nandita; Mande, Shekhar C; Johnston, Jodie M; Lott, J Shaun; Baker, Edward N; Arcus, Vickery L; Leys, David; McLean, Kirsty J; Munro, Andrew W; Berendzen, Joel; Sharma, Vivek; Park, Min S; Eisenberg, David; Sacchettini, James; Alber, Tom; Rupp, Bernhard; Jacobs, William; Terwilliger, Thomas C

Goulding, Celia W; Apostol, Marcin; Anderson, Daniel H; Gill, Harindarpal S; Smith, Clare V; Kuo, Mack R; Yang, Jin Kuk; Waldo, Geoffrey S; Suh, Se Won; Chauhan, Radha; Kale, Avinash; Bachhawat, Nandita; Mande, Shekhar C; Johnston, Jodie M; Lott, J Shaun; Baker, Edward N; Arcus, Vickery L; Leys, David; McLean, Kirsty J; Munro, Andrew W; Berendzen, Joel; Sharma, Vivek; Park, Min S; Eisenberg, David; Sacchettini, James; Alber, Tom; Rupp, Bernhard; Jacobs, William; Terwilliger, Thomas C.

Afiliação

Goulding CW; Bioscience Division, Mail Stop M888, Los Alamos National Laboratory, Los Alamos, NM 87545, USA.

Curr Drug Targets Infect Disord ; 2(2): 121-41, 2002 Jun.

Article em En | MEDLINE | ID: mdl-12462144

ABSTRACT

ABSTRACT

Structural genomics, the large-scale determination of protein structures, promises to provide a broad structural foundation for drug discovery. The tuberculosis (TB) Structural Genomics Consortium is devoted to encouraging, coordinating, and facilitating the determination of structures of proteins from Mycobacterium tuberculosis and hopes to determine 400 TB protein structures over 5 years. The Consortium has determined structures of 28 proteins from TB to date. These protein structures are already providing a basis for drug discovery efforts.

Assuntos

Aciltransferases; Antibacterianos/farmacologia; Antígenos de Bactérias; Proteínas de Bactérias/química; Desenho de Fármacos; Genômica; Mycobacterium tuberculosis/química; Mycobacterium tuberculosis/efeitos dos fármacos; Aldeído Liases/química; Sistema Enzimático do Citocromo P-450/química; Glutamato-Amônia Ligase/química; Metiltransferases/química; Mio-Inositol-1-Fosfato Sintase/química; Oxirredutases/química; Isomerases de Dissulfetos de Proteínas/química

Buscar no Google

Imprimir

XML

PubMed Links

Base de dados: MEDLINE Assunto principal: Proteínas de Bactérias / Aciltransferases / Desenho de Fármacos / Genômica / Antibacterianos / Mycobacterium tuberculosis / Antígenos de Bactérias Idioma: En Revista: Curr Drug Targets Infect Disord Assunto da revista: DOENCAS TRANSMISSIVEIS / TERAPIA POR MEDICAMENTOS Ano de publicação: 2002 Tipo de documento: Article País de afiliação: Estados Unidos

Buscar no Google

Imprimir

XML

PubMed Links