Pharmacokinetics of anti-D IgG in pregnant RhD-negative women.
BJOG
; 110(1): 39-45, 2003 Jan.
Article
em En
| MEDLINE
| ID: mdl-12504934
ABSTRACT
OBJECTIVE:
To assess the pharmacokinetics of anti-D IgG in pregnant Rhesus D-negative women after intramuscular and intravenous administration of 300 microg of Rhophylac.DESIGN:
An open, randomised, multicentre study.SETTING:
Seven gynaecological practices in Germany. SAMPLE Fourteen RhD-negative pregnant women at risk of becoming Rhesus D immunised received study drug at 28th week of pregnancy either by intramuscular or intravenous route. MAIN OUTCOMEMEASURES:
Anti-D IgG concentrations of serum samples obtained up to 11 weeks following antenatal Rhesus D prophylaxis were quantified by flow cytometry.RESULTS:
Mean anti-D IgG concentrations after intravenous and intramuscular administration differed up to seven days post-injection, from two weeks onwards they were comparable to each other. Irrespective of the administration route, anti-D IgG in serum was detectable in all women up to at least nine weeks post-administration.CONCLUSIONS:
The serum concentrations of anti-D IgG measured after administration of Rhophylac were very similar to those obtained with 300 microg of a different anti-D immunoglobulin product.
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Base de dados:
MEDLINE
Assunto principal:
Complicações Hematológicas na Gravidez
/
Isoimunização Rh
/
Imunoglobulina rho(D)
/
Isoanticorpos
Tipo de estudo:
Clinical_trials
Limite:
Adult
/
Female
/
Humans
/
Pregnancy
Idioma:
En
Revista:
BJOG
Assunto da revista:
GINECOLOGIA
/
OBSTETRICIA
Ano de publicação:
2003
Tipo de documento:
Article
País de afiliação:
Suíça