Idiotype-pulsed dendritic cells are able to induce antitumoral cytotoxic CD8 cells in chronic lymphocytic leukaemia.
Br J Haematol
; 120(2): 243-50, 2003 Jan.
Article
em En
| MEDLINE
| ID: mdl-12542481
ABSTRACT
Idiotypic structures of immunoglobulins from malignant B cells constitute tumour-specific antigens, though the function of immunoglobulin-specific CD8+ T cells in disease control and rejection remains unclear. We have studied five cases of B chronic lymphocytic leukaemia patients affected with indolent (three patients) or aggressive (two patients) disease. We showed that CD8+ T cells with major histocompatibility complex class I-restricted cytotoxicity against autologous tumour B cells could be generated following repeated stimulations with idiotype-pulsed dendritic cells in vitro. CD8+ T-cell lines were able to upregulate CD69 expression and to release interferon (IFN)-gamma upon contact with the autologous B cells, though cytolytic activity was only substantiated for patients with indolent disease. The failure of cytolytic activity in patients with aggressive disease may be explained by a skewed maturation of memory CD8 cells.
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Base de dados:
MEDLINE
Assunto principal:
Células Dendríticas
/
Linfócitos T Citotóxicos
/
Leucemia Linfocítica Crônica de Células B
/
Imunoterapia Adotiva
/
Antígenos CD8
Limite:
Humans
Idioma:
En
Revista:
Br J Haematol
Ano de publicação:
2003
Tipo de documento:
Article
País de afiliação:
França