Nonsuppressible insulin-like activity of human serum. A potent inhibitor of insulin degradation.
J Clin Invest
; 57(2): 526-9, 1976 Feb.
Article
em En
| MEDLINE
| ID: mdl-1254732
ABSTRACT
Nonsuppressible insulin-like activity soluble in acid ethanol (NSILA-s) is a well-characterized peptide derived from human serum which has previously been shown to have insulin-like bioactivity and react with both insulin and NSILA-s receptor sites in liver plasma membranes. In the present study we find that NSILA-s is also a potent competitive inhibitor of the insulin-degrading system of the liver plasma membrane. The most purified NSILA-s preparation tested was 20-fold more potent than insulin itself, and significant inhibition of insulin degradation occurred at concentrations of NSILA-s similar to those found in plasma.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Proteínas Sanguíneas
/
Insulina
/
Fígado
Limite:
Humans
Idioma:
En
Revista:
J Clin Invest
Ano de publicação:
1976
Tipo de documento:
Article