Identification of genes that protect the C. elegans genome against mutations by genome-wide RNAi.
Genes Dev
; 17(4): 443-8, 2003 Feb 15.
Article
em En
| MEDLINE
| ID: mdl-12600937
ABSTRACT
An RNA interference (RNAi)-based genome-wide screen was performed to detect genes that contribute to genome stability in somatic cells of Caenorhabditis elegans. We identified 61 such genes; these also affect spontaneous mutagenesis in the germ line. Their sequence suggests a role in DNA repair and/or replication, in chromatin remodeling, or in cell cycle control; there are also many novel genes that are highly conserved from yeast to human. Because known mutator genes are causally involved in many hereditary and sporadic human cancers, it is likely that some of these new mutators are equally relevant in cancer etiology.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Genes de Helmintos
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Caenorhabditis elegans
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Interferência de RNA
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Proteínas de Membrana
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Mutação
Tipo de estudo:
Diagnostic_studies
Limite:
Animals
Idioma:
En
Revista:
Genes Dev
Assunto da revista:
BIOLOGIA MOLECULAR
Ano de publicação:
2003
Tipo de documento:
Article
País de afiliação:
Holanda