Effects of repeated stress on regeneration of serotonergic and noradrenergic axons in the cerebral cortex of adult rats.
Neurosci Lett
; 339(3): 227-30, 2003 Mar 27.
Article
em En
| MEDLINE
| ID: mdl-12633894
ABSTRACT
We examined whether regeneration of serotonergic (5-HT) and noradrenergic (NA) axons might be affected by stress. Neurotoxins to 5-HT or NA axons were injected into the frontal cortex to cause partial denervation. Mild restraint stress (40 min/day) was started 16 days later and given for 14 consecutive days (30-day stressed group). Non-stressed animals were divided into two groups, animals sacrificed at 14 days (14-day control group) and those sacrificed at 30 days (30-day control group) after the toxin injection. In immunohistochemical study, the denervation area of 5-HT axons but not that of NA axons was significantly smaller in the 30-day control group than in the 14-day control group. However, there was no significant difference between the 14-day control and 30-day stressed groups. These findings suggested that regeneration of 5-HT axons occurred earlier than that of NA axons, and that stress exerted inhibitory influence on regeneration of 5-HT axons.
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Base de dados:
MEDLINE
Assunto principal:
Estresse Fisiológico
/
Axônios
/
Serotonina
/
Norepinefrina
/
Regeneração Nervosa
Limite:
Animals
Idioma:
En
Revista:
Neurosci Lett
Ano de publicação:
2003
Tipo de documento:
Article
País de afiliação:
Japão